AMBIT

Consists of

• a relational database database schema, allowing to store and query all relevant structure and property information, including data for toxicity endpoints from various sources and formats. Can handle very large number of structures efficiently
• functional modules allowing a variety of evaluations flexible structure, similarity and other information retrieval. Used in both standalone and web (servlets/taglibs based) applications

Applications:

1. Ambit Database tools 1.30 (Java, LGPL) (Standalone database query and management interface )
2. Ambit Discovery (Java, LGPL) (Applicability domain assessment)
3. Ambit Online (Demo application allowing to query AMBIT database online)
4. QMRF Repository (Web based portal for submitting documents in QMRF format)
5. AMBIT XT (Workflow based application )

AMBIT XT (Java, LGPL)

Objective: Develop an open source user friendly software, providing a set of functionalities to facilitate registration of the chemicals for REACH.

Under development, first release December 2008, final release July 2009

• Built upon AMBIT
• Workflow support (embedded workflow engine)
• Modular application (flexible plug-in support)
• Implements a set of workflows, defined by the industry (e.g. analogue identification, PBT assessment, etc.)

Database

• Improved database schema

Data provenance

• History of the origin and updates of the chemicals information.
• Data quality
• Easy way for comparison between different sources
• Flexible storage for measured toxicological data for different endpoints
• Easy way to extract all relevant information for a chemical; many formats available for toxicological data
• Easy entry of complex structural alerts to facilitate grouping

Molecular descriptors

User interface and reporting

• Recording of user actions
• Improved data entrance and visualization
• Reporting compatible with IUCLID 5

• Homepage: http://ambit.sourceforge.net
• Subproject of: OpenTox
• Data: Yes
• Software: Yes
• Programming language: Java, JSP
• Operating system: Any
• Dependencies: Multiple open source libraries
• Interface: Java Swing, Web
• Input format: Multiple text formats, MySQL database, User interface
• Output format: Multiple text formats, MySQL database, User interface
• Version control: SVN
• License: LGPL