OpenTox

The overall objective of the proposed project is to develop a framework, that provides a unified access to toxicity data, (Q)SAR models, procedures supporting validation and additional information that helps with the interpretation of (Q)SAR predictions. The proposed OpenTox framework will be accessible at three levels:

• A simple and intuitive interface for toxicological experts, that provides unified access to (Q)SAR predictions, toxicological data, (Q)SAR models and supporting information
• An expert interface for the streamlined development and validation of new (Q)SAR models
• An application programming interface (API) for the development, integration and validation of new (Q)SAR algorithms

The OpenTox framework will be developed as an open source project to optimize the dissemination and impact, to allow the inspection and review of algorithms and to attract external contributors. We will closely collaborate with related projects (e.g. OECD toolbox) and authorities to agree on common standards and to avoid duplicated and redundant work.

• Homepage: www.opentox.org
• Subprojects: AMBIT, DSSTox data for lazar, FreeTreeMiner, LibFminer, RUMBLE, Sens-it-iv internal database, Toxmatch, Toxtree, gSpan', iSAR, lazar, lazar plugin, lazar web interface, opentox-plugin